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Structural Transitions in poly(A), poly(C), poly(U), and poly(G) and Their Possible Biological Roles

Structural Transitions in poly(A), poly(C), poly(U), and poly(G) and Their Possible Biological Roles

Margarita I Zarudnaya, Iryna M Kolomiets, Andriy L Potyahaylo, Dmytro M Hovorun

J Biomol Struct Dyn. 2019 Jul;37(11):2837-2866.

PMID: 30052138

Abstract:

The homopolynucleotide (homo-oligonucleotide) tracts function as regulatory elements at various stages of mRNAs life cycle. Numerous cellular proteins specifically bind to these tracts. Among them are the different poly(A)-binding proteins, poly(C)-binding proteins, multifunctional fragile X mental retardation protein which binds specifically both to poly(G) and poly(U) and others. Molecular mechanisms of regulation of gene expression mediated by homopolynucleotide tracts in RNAs are not fully understood and the structural diversity of these tracts can contribute substantially to this regulation. This review summarizes current knowledge on different forms of homoribopolynucleotides, in particular, neutral and acidic forms of poly(A) and poly(C), and also biological relevance of homoribopolynucleotide (homoribo-oligonucleotide) tracts is discussed. Under physiological conditions, the acidic forms of poly(A) and poly(C) can be induced by proton transfer from acidic amino acids of proteins to adenine and cytosine bases. Finally, we present potential mechanisms for the regulation of some biological processes through the formation of intramolecular poly(A) duplexes.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP26936403	poly(C)		26936-40-3	Price

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