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Structure and Mechanism of AMPA Receptor - Auxiliary Protein Complexes

Structure and Mechanism of AMPA Receptor - Auxiliary Protein Complexes

Shanshuang Chen, Eric Gouaux

Curr Opin Struct Biol. 2019 Feb;54:104-111.

PMID: 30825796

Abstract:

Ionotropic glutamate receptors in vertebrates are composed of three major subtypes - AMPA, kainate, and NMDA receptors - and mediate the majority of fast excitatory neurotransmission at chemical synapses of the central nervous system. Among the three major families, native AMPA receptors function as complexes with a variety of auxiliary subunits, which in turn modulate receptor trafficking, gating, pharmacology, and permeation. Despite the long history of structure-mechanism studies using soluble receptor domains or intact yet isolated receptors, structures of AMPA receptor-auxiliary subunit complexes have not been available until recent breakthroughs in single-particle cryo-electron microscopy. Single particle cryo-EM studies have, in turn, provided new insights into the structure and organization of AMPA receptor - auxiliary protein complexes and into the molecular mechanisms of AMPA receptor activation and desensitization.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP74341632	(±)-AMPA		74341-63-2	Price

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