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Structure and Stability of Columnar Cyclomaltooctaose (Gamma-Cyclodextrin) Hydrate

Structure and Stability of Columnar Cyclomaltooctaose (Gamma-Cyclodextrin) Hydrate

Marcus A Hunt, Cristian C Rusa, Alan E Tonelli, C Maurice Balik

Carbohydr Res. 2005 Jul 4;340(9):1631-7.

PMID: 15927169

Abstract:

Rapid recrystallization of cyclomaltooctaose (gamma-cyclodextrin, gamma-CD) from aqueous solution resulted in formation of a columnar structure with only water as the guest molecule. Upon vacuum drying at 90 degrees C for 15 h, gamma-CD, which was initially in the columnar structure, became amorphous. Complementary water vapor sorption and wide-angle X-ray diffractometry experiments were performed on columnar gamma-CD in its vacuum dried and as-precipitated states to elucidate its stability in humid environments and the crystal structure present at varying sorption levels. These experiments show that both types of gamma-CD transform to the cage crystal structure upon exposure to water vapor at 40 degrees C and with an activity of 1.0. Sorption equilibrium is reached long before the crystal structure transformation is complete, indicating that a significant amount of molecular mobility exists in the various hydrated gamma-CD crystal structures.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP91464903	γ-Cyclodextrin hydrate		91464-90-3	Price

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