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Structure Elucidation and Anticancer Activity of 7-oxostaurosporine Derivatives From the Brazilian Endemic Tunicate Eudistoma Vannamei

Paula Christine Jimenez, Diego Veras Wilke, Elthon Gois Ferreira, Renata Takeara, Manoel Odorico de Moraes, Edilberto Rocha da Silveira, Tito Monteiro da Cruz Lotufo, Norberto Peporine Lopes, Leticia Veras Costa-Lotufo

Mar Drugs. 2012 May;10(5):1092-102.

PMID: 22822359

Abstract:

The present study reports the identification of two new staurosporine derivatives, 2-hydroxy-7-oxostaurosporine (1) and 3-hydroxy-7-oxostaurosporine (2), obtained from mid-polar fractions of an aqueous methanol extract of the tunicate Eudistoma vannamei, endemic to the northeast coast of Brazil. The mixture of 1 and 2 displayed IC₅₀ values in the nM range and was up to 14 times more cytotoxic than staurosporine across a panel of tumor cell lines, as evaluated using the MTT assay.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP125035838 7-Oxostaurosporine 7-Oxostaurosporine 125035-83-8 Price
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