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Structures of Human Acetylcholinesterase in Complex With Pharmacologically Important Ligands

Jonah Cheung, Michael J Rudolph, Fiana Burshteyn, Michael S Cassidy, Ebony N Gary, James Love, Matthew C Franklin, Jude J Height

J Med Chem. 2012 Nov 26;55(22):10282-6.

PMID: 23035744

Abstract:

Human acetylcholinesterase (AChE) is a significant target for therapeutic drugs. Here we present high resolution crystal structures of human AChE, alone and in complexes with drug ligands; donepezil, an Alzheimer's disease drug, binds differently to human AChE than it does to Torpedo AChE. These crystals of human AChE provide a more accurate platform for further drug development than previously available.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP9000811 Acetylcholinesterase human Acetylcholinesterase human 9000-81-1 Price
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