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Studies on Optimization of a Platinum Catalyst and Porphine Modified, Pyrolytic Graphite, Amperometric, Glucose Sensor by Sequential Level Elimination Experimental Design

Studies on Optimization of a Platinum Catalyst and Porphine Modified, Pyrolytic Graphite, Amperometric, Glucose Sensor by Sequential Level Elimination Experimental Design

L X Sun, F Xu 1, T Okada

Talanta. 1998 Dec;47(5):1165-74.

PMID: 18967422

Abstract:

A new amperometric glucose sensor based on the glucose oxidase immobilized on pyrolytic graphite (PG) modified with tetraammineplatinum(II) chloride (TAPtCl) and 5,10,15,20-tetrakis (4-methoxy-phenyl)-21H,23H-porphine cobalt(II) (TMPPCo) as well as Nafion was studied. The performances amongst the glucose sensors with or without TAPtCl or/and TMPPCo measured with oxygen present in the solution were compared. The compositions of the membranes of the glucose sensors were optimized by a new orthogonal experimental design technique-sequential level elimination method according to chemometric approaches. Our studies show that the prepared sensor with optimal membrane composition in this study gives satisfactory performance in terms of long-term stability, fast amperometric response, good detection limits and satisfactory recovery. The study provides a useful basis for developing other sensors with corresponding optimal membranes.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP28903711	5,10,15,20-Tetrakis(4-methoxyphenyl)-21H,23H-porphine cobalt(II)		28903-71-1	Price

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