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[Studies on the Biotransformation of Escin Ia by Human Intestinal Bacteria and the Anti-Tumor Activities of Desacylescin I]

[Studies on the Biotransformation of Escin Ia by Human Intestinal Bacteria and the Anti-Tumor Activities of Desacylescin I]

Xiu-Wei Yang, Jing Zhao, Jing-Rong Cui, Wei Guo

Beijing Da Xue Xue Bao Yi Xue Ban. 2004 Feb;36(1):31-5.

PMID: 14970884

Abstract:

Objective:
To study Biotransformation of escin Ia by the crude enzymes of human intestinal bacteria and Lactobacillus brevis, determine the structures of biotransformation products and assay the inhibitory effect of desacylescin I on the tumor cell growth.
Methods:
The escin Ia was incubated with crude enzymes of human intestinal bacteria and Lactobacillus brevis in vitro, respectively. The biotransformation products were isolated and purified by the chromatographic methods and the structures were determined by the spectroscopic techniques.
Results:
Escin Ia was converted into isoescin Ia, desacylescin I, 21beta-O-tigloylprotoaescigenin and protoaescigenin by crude enzymes of human intestinal bacteria and Lactobacillus brevis. Desacylescin I showed potentially inhibitory effects on tumor cell growth of mouse sarcoma-180, hepatic carcinoma H(22) and lung carcinoma in vivo.
Conclusion:
The results suggest that Escin Ia was a prodrug and its structure can be converted by human intestinal bacteria and Lactobacillus brevis. Desacylescin I as a biotransformation product showed potentially inhibitory effects on mouse tumor, and a potential candidate for anti tumor agents.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP219944395	Isoescin IA		219944-39-5	Price

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