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Studies on the Biotransformation of Paeonol by Means of Isotope Tracer techniques.--Synthesis and Physicochemical Properties of carbon-13 and Deuterium Labeled Compounds--

Studies on the Biotransformation of Paeonol by Means of Isotope Tracer techniques.--Synthesis and Physicochemical Properties of carbon-13 and Deuterium Labeled Compounds--

K Mimura, S Baba

Radioisotopes. 1979 Dec;28(12):739-44.

PMID: 545436

Abstract:

In order to perform the metabolic study of paeonol (I) in human and animals by using isotope tracer techniques, synthesis of I and its urinary metabolites labeled with carbon-13 or deuterium was investigated. 2-Hydroxy-4-methoxy[d3]acetophenone, 2,5-dihydroxy-4-methoxy[d3]acetophenone, and resacetophenone[acetyl-13C2] were synthesized from methyl iodide-d3, dimethyl sulfate-d6, and acetic acid-1,2-13C2, respectively. Physicochemical studies by IR and NMR spectra showed that stable isotope was not eliminated during the synthetic process of each compound. For the quantification of the metabolites by GC-MS analysis, isotope effect on gas chromatography and fragmentation was studied.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP286437169	DL-Lysine-1,2-13C2 dihydrochloride		286437-16-9	Price

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