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Studies on the SAR and Pharmacophore of Milnacipran Derivatives as Monoamine Transporter Inhibitors

Chen Chen, Brian Dyck, Beth A Fleck, Alan C Foster, Jonathan Grey, Florence Jovic, Michael Mesleh, Kasey Phan, Junko Tamiya, Troy Vickers, Mingzhu Zhang

Bioorg Med Chem Lett. 2008 Feb 15;18(4):1346-9.

PMID: 18207394

Abstract:

Derivatives of milnacipran were synthesized and studied as monoamine transporter inhibitors. Potent analogs were discovered at NET (9k) and at both NET and SERT (9s and 9u). A pharmacophore model was established based on the conformational analysis of milnacipran in aqueous solution using NMR techniques and was consistent with the SAR results.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP101152947-A Milnacipran hydrochloride solution Milnacipran hydrochloride solution 101152-94-7 Price
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