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Study and Analytical Application of Ion-Pair Formation in the System Fluoxetine-Pyrocatechol Violet and Fluvoxamine-Pyrocatechol Violet

B Starczewska, A Jasińska, B Białous

Pharmazie. 2003 Apr;58(4):245-8.

PMID: 12749405

Abstract:

Pyrocatechol violet (PCV) reacts in aqueous media with fluoxetine (FLX) and fluvoxamine (FLV) forming coloured ion-association complexes, which are insoluble in water but quantitatively extracted into chloroform-n-butanol mixture. The composition of the compounds, studied by spectrophotometric methods showed that the molar ratio PCV : FLX and PCV : FLV is 1 : 1. The compounds were characterized by UV-VIS, IR and NMR spectrometry. Under optimal experimental conditions fluoxetine and fluvoxamine were determined in the range 1.3-18.0 microg/ml and 2.6-39.1 microg/ml, respectively. The proposed methods have been succesfully applied to the determination of these drugs in pharmaceuticals and natural samples.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP115413 Pyrocatechol Violet Pyrocatechol Violet 115-41-3 Price
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