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Study of the Interactions of PAMAM G3-NH2 and G3-OH Dendrimers With 5-fluorouracil in Aqueous Solutions

Study of the Interactions of PAMAM G3-NH2 and G3-OH Dendrimers With 5-fluorouracil in Aqueous Solutions

Adam Buczkowski, Dariusz Waliszewski, Pawel Urbaniak, Bartlomiej Palecz

Int J Pharm. 2016 May 30;505(1-2):1-13.

PMID: 27039147

Abstract:

The results of spectroscopic measurements (increase in solubility, equilibrium dialysis, (1)H NMR titration) and calorimetric measurements (isothermal titration ITC) indicate spontaneous (ΔG<0) bonding of 5-fluorouracil by both cationic PAMAM G3-NH2 dendrimer and hydroxyl PAMAM G3-OH dendrimer in aqueous solutions. PAMAM G3-NH2 dendrimer bonds about n= 25±8 drug molecules. Some of them n1= 5±1 are bonded by terminal amine groups with equilibrium constant K1= 3890±930, while the remaining ones n2= 24 ±3 are bonded by amide groups with equilibrium constant K2= 110±30. Hydroxyl PAMAM G3-OH dendrimer bonds n=6.0±1.6 molecules of 5-fluorouracil through tertiary amine groups with equilibrium constant K= 65±10. The parameters of bonding 5-fluorouracil by PAMAM G3-NH2 and G3-OH dendrimer were compared with those of bonding this drug by the macromolecules of PAMAM of generations G4-NH2, G5-NH2 and G5-OH.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
LS76299	PAMAM-OH dendrimer, generation 5 solution			Price

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