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[Study on Anti-Bacterium Activity of Ginkgolic Acids and Their Momomers]

[Study on Anti-Bacterium Activity of Ginkgolic Acids and Their Momomers]

Xiaoming Yang, Wei Zhu, Jun Chen, Zhiyu Qian, Jimin Xie

Zhong Yao Cai. 2004 Sep;27(9):661-3.

PMID: 15704587

Abstract:

Objective:
Ginkgolic acids and their three monomers were separated from ginkgo sarcotestas. The anti-bacterium activity of ginkgolic acids were tested. The relation between the anti-bacterium activity and side chain of ginkgolic acid were studied.
Method:
The MIC of ginkgolic acids and their three monomers and salicylic acid were tested.
Results:
Ginkgolic acid has strong inhibitive effect on G+-bacterium. Salicylic acid has no side chain, so no anti-bacterial activity. When the length of gingkolic acid side chain is C13:0, it has the strongest anti-bacterial activity in three monomers.
Conclusion:
The side chain of ginkgolic acid is the key functional group that possessed anti-bacterial activity. The length of Ginkgolic acid was the main effective factor of anti-bacterial activity.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP20261385	Ginkgolic acid C13:0		20261-38-5	Price

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