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Study on Apoptosis Effect of Human Breast Cancer Cell MCF-7 Induced by Lycorine Hydrochloride via Death Receptor Pathway

Study on Apoptosis Effect of Human Breast Cancer Cell MCF-7 Induced by Lycorine Hydrochloride via Death Receptor Pathway

Yubin Ji, Miao Yu, Zheng Qi, Di Cui, Guosong Xin, Bing Wang, Weiling Jia, Lin Chang

Saudi Pharm J. 2017 May;25(4):633-637.

PMID: 28579903

Abstract:

As research was conducted on the early apoptosis of human breast cancer cell MCF-7 caused by lycorine hydrochloride and the expression of the related apoptosis proteins. The early-period apoptosis rate of human breast cancer cell MCF-7 was tested with the AnnexinV/PI double staining and flow cytometry. The Western Blotting method was also used to detect the protein expression conditions of Fas, FasL, Caspase-8 and Bid. The results showed that the higher the dose, the higher the rate of apoptosis and that the rate of apoptosis was dependent on the dose; the relative protein activity of Fas, FasL, Caspase-8 and bid gradually rose with the increase of lycorine dosage and the activities revealed certain dose-independence. Results showed that lycorine hydrochloride could induce the apoptosis of human breast cancer cell MCF-7 through the death receptor pathway.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP2188683	Lycorine hydrochloride		2188-68-3	Price

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