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[Study on Screening Antitumor Active Fractions and Chemical Components in Active Fractions From Root of Anaycclus Pyrethrum]

[Study on Screening Antitumor Active Fractions and Chemical Components in Active Fractions From Root of Anaycclus Pyrethrum]

Jie Dong, Jiang Yuan, Jia-Li Wang, Rui-Fang Ji, Qing-Hua Quan, Xiao-Yu Guo, Jian Gao, Yong-Gang Liu

Zhongguo Zhong Yao Za Zhi. 2017 Oct;42(20):3932-3937.

PMID: 29243430

Abstract:

Components that systematic separated from the root of Anaycclus pyrethrum were identified, in order to lay a foundation for future study of the root of A. pyrethrum. The CCK-8 assay showed that dichloromethane fraction exhibited the highest degree of cytotoxicity than others. Ten monomeric components were obtained from dichloromethane fraction and ethyl acetate fraction extracted from the root of A. pyrethrum, including 7 N-alkylamides, one coumarin and two flavonoid glycosides. They were identified as tetradeca-2E,4E,8E-trienoic acid 4-hydroxyphenylethylamide(1), deca-2E,4E-dienoicacid isobutylamide(2), undeca-2E,4E-diene-8,10-diynoic acid phenylethylamide(3), tetradeca-2E,4E-dienoic acid 4-hydroxyphenylethylamide(4), tetradeca-2E,4E-diene-8,10-diynoic acid isobutylamide(5), deca-2E,4E- dienoic acid 4-hydroxyphenylethylamide(6), dodeca-2E,4E-dienoic acid 4-hydroxy -phenyl-ethylamide(7), isoscopoletin(8), quercetin-7-O-β-D-glucopyranoside(9), isorhamnetin-7-O-β-D-glucopyranoside(10). Among them, compound 1 was identified as a new compound, Compounds 2-4, 8-10 were isolated from this herb for the first time.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP82240093	2E,4E-Hexadienoic acid isobutylamide		82240-09-3	Price

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