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Study on Synthesis of Key Squalamine Intermediate 7α, 24R-dihydroxy-5α-cholestan-3-one

Shuai Zhou, Yang Zheng, Beibei Yang, Jiawei Zhong, Haijian Shi

Steroids. 2019 Nov;151:108472.

PMID: 31400392

Abstract:

A facile novel strategy has been developed to obtain a key intermediate of squalamine, 7α, 24R -dihydroxy-5α-cholestan-3-one, starting from methyl Δ5-3β-hydroxycholanate. The pure product was successfully synthesized and separated from the C-24 position epimers in good purity, d.e.% and yield.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP566881 5α-Cholestan-3-one 5α-Cholestan-3-one 566-88-1 Price
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