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Subclass Restriction of the Antiidiotypic Antibody Response in the Rat

Subclass Restriction of the Antiidiotypic Antibody Response in the Rat

R Rousseaux-Prévost, J Bonneterre, H Bazin, J Rousseaux

Ann Immunol (Paris). Sep-Oct 1983;134D(2):167-79.

PMID: 6607024

Abstract:

Antiidiotypic antibodies were induced in LOU/M rats by immunization with two myeloma proteins of LOU origin: IR-162 (IgE) and IR-418 (IgG2a). Antibodies to IR-162 were easily obtained after a limited number of immunizations with protein in soluble form; polymerization with glutaraldehyde did not enhance immunogenicity. Antibodies to IR-418 appeared only after a large number of immunizations with protein in polymerized form or with protein copolymerized with rabbit IgG. All of the antibodies, either to IR-162 or to IR-418, were found to be idiotype-specific. In every case for which significant levels of antiidiotypic antibodies were produced, most or all of the antibodies belonged to rat IgG1 subclass. Since, in mice, antiidiotypic antibodies are restricted to the IgG1 subclass, our results indicate a functional analogy between rat and mouse IgG1. Our studies also suggest that the rat IgG1 subclass may be predominantly expressed in T-cell-dependent antibody responses, such as production of antiidiotypic antibodies.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42417527	Anti-phospho-EPB41 (pTyr660/418) antibody produced in rabbit			Price

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