Home
Resources
Publications
Subcutaneous Nicotine Delivery via Needle-Free Jet Injection: A Porcine Model

Subcutaneous Nicotine Delivery via Needle-Free Jet Injection: A Porcine Model

Bryan P Ruddy, Chris Bullen, Joanna Ting Wai Chu, Soo Hee Jeong, Bahareh Madadkhahsalmassi, James W McKeage, Darren Svirskis, Malcolm D Tingle, Jiali Xu, Andrew J Taberner

J Control Release. 2019 Jul 28;306:83-88.

PMID: 31150748

Abstract:

Subcutaneous delivery of nicotine was performed using a novel electrically-operated needle-free jet injector, and compared to hypodermic needle delivery in a porcine model. Nicotine was delivered as a single, one-milligram dose into the abdominal skin, formulated as a 50 microliter aqueous solution. Plasma levels of nicotine and cotinine, its main metabolite, were then monitored over 2 h, following which the injection site was excised for histological examination. No irritation or tissue damage were found at the injection sites, and the jet-injected nicotine exhibited comparable absorption into the systemic circulation to that injected using a conventional needle and syringe. The needle-free jet injection of nicotine is a promising and well tolerated method. The data presented from this porcine model will support a first in human trial towards a new promising nicotine replacement therapy.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AS21411	(−)-Cotinine solution			Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: