0

Successful Treatment of a Complicated Case of Neuroleptic Malignant Syndrome

A Lappa, M Podestà, O Capelli, A Castagna, G Di Placido, D Alampi, F Semeraro

Intensive Care Med. 2002 Jul;28(7):976-7.

PMID: 12122539

Abstract:

Neuroleptic malignant syndrome (NMS) is a life-threatening reaction often related to neuroleptic drugs, characterized by rigidity, hyperthermia, altered consciousness, and fluctuating blood pressure. We present a case of NMS that followed a doubled oral dose of a drug compound: tranylcypromine sulfate, a monoamine oxidase inhibitor, and trifluoperazine (neuroleptic). The case was complicated by rhabdomyolisis and disseminated intravascular coagulation. It was treated successfully with dantrolene sodium and generous fluid therapy without using neuromuscular blocking agents or dopamine agonists.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP301359057 Dantrolene Related Compound A Dantrolene Related Compound A 301359-05-7 Price
AP54779587 Tranylcypromine Related Compound A Tranylcypromine Related Compound A 54779-58-7 Price
qrcode