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[Successful Use of Levosimendan in a Patient With Cardiogenic Shock Complicating Acute Myocardial Infarction]

[Successful Use of Levosimendan in a Patient With Cardiogenic Shock Complicating Acute Myocardial Infarction]

Ferjani Mustapha, Hamdi Moufida, Barakette Nedia, Lebbi Anis, Labbene Iheb, Haouala Habib

Tunis Med. 2005 Oct;83(10):635-7.

PMID: 16370217

Abstract:

Levosimendan is a new inodilator that improves cardiac contractility by sensitizing troponin C to calcium. This drug has proved to be effective in treating advanced congestive heart failure but has not been evaluated in cardiogenic shock. We present the case of a 54-year-old male patient treated successfully with levosimendan for cardiogenic shock following acute myocardial infarction. Treatment with dobulamine. revascularisation and itra-aortic balloon conterpulsation had first failed to improve his hemodynamic variables. Levosimendan induced a steady decline of increased pulmonary capillary wedge pressure, followed by an increase in cardiac index and mixed venous oxygen saturation. Left ventricular ejection fraction improved from 25% to 47%. Infusion of levosimendan can be used in cardiogenic shock without side effects and to improve hemodynamics and left ventricular function.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP671225391-A	Cardiogenol C - CAS 671225-39-1		671225-39-1	Price

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