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Succinate: A Metabolic Signal in Inflammation

Succinate: A Metabolic Signal in Inflammation

Evanna Mills, Luke A J O'Neill

Trends Cell Biol. 2014 May;24(5):313-20.

PMID: 24361092

Abstract:

Succinate is an intermediate of the tricarboxylic acid (TCA) cycle, and plays a crucial role in adenosine triphosphate (ATP) generation in mitochondria. Recently, new roles for succinate outside metabolism have emerged. Succinate stabilizes the transcription factor hypoxia-inducible factor-1α (HIF-1α) in specific tumors and in activated macrophages, and stimulates dendritic cells via its receptor succinate receptor 1. Furthermore, succinate has been shown to post-translationally modify proteins. This expanding repertoire of functions for succinate suggests a broader role in cellular activation. We review the new roles of succinate and draw parallels to other metabolites such as NAD(+) and citrate whose roles have expanded beyond metabolism and into signaling.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
LS7411337	4arm-PEG40K-Succinimidyl Succinate			Price
LS7411393	8arm-PEG40K-Succinimidyl Succinate			Price

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