Home
Resources
Publications
Sulfur-containing Cytotoxic Curvularin Macrolides From Penicillium Sumatrense MA-92, a Fungus Obtained From the Rhizosphere of the Mangrove Lumnitzera Racemosa

Sulfur-containing Cytotoxic Curvularin Macrolides From Penicillium Sumatrense MA-92, a Fungus Obtained From the Rhizosphere of the Mangrove Lumnitzera Racemosa

Ling-Hong Meng, Xiao-Ming Li, Cui-Ting Lv, Chun-Shun Li, Gang-Ming Xu, Cai-Guo Huang, Bin-Gui Wang

J Nat Prod. 2013 Nov 22;76(11):2145-9.

PMID: 24195466

Abstract:

Sumalarins A-C (1-3), the new and rare examples of sulfur-containing curvularin derivatives, along with three known analogues (4-6), were isolated and identified from the cytotoxic extract of Penicillium sumatrense MA-92, a fungus obtained from the rhizosphere of the mangrove Lumnitzera racemosa . Their structures were established by detailed interpretation of NMR and MS data, and compound 1 was confirmed by X-ray crystallographic analysis. Compounds 1-3 and 5 showed potent cytotoxicity against some of the tested tumor cell lines. Sulfur substitution at C-11 or a double bond at C-10 significantly increased the cytotoxic activities of the curvularin analogues.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP10140702	Curvularin		10140-70-2	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: