Home
Resources
Publications
Supplementation of Diets for Gestating Sows With Zinc Amino Acid Complex and Gastric Intubation of Suckling Pigs With Zinc-Methionine on Mineral Status, Intestinal Morphology and Bacterial Translocation in Lipopolysaccharide-Challenged Early-Weaned Pigs

Supplementation of Diets for Gestating Sows With Zinc Amino Acid Complex and Gastric Intubation of Suckling Pigs With Zinc-Methionine on Mineral Status, Intestinal Morphology and Bacterial Translocation in Lipopolysaccharide-Challenged Early-Weaned Pigs

W R Caine, B U Metzler-Zebeli, M McFall, B Miller, T L Ward, R N Kirkwood, R Mosenthin

Res Vet Sci. 2009 Jun;86(3):453-62.

PMID: 19062056

Abstract:

Eighty male pigs from 20 litters were used to evaluate dietary addition of 250mg/kg of Zn from zinc amino acid complex (ZnAA) to sows during the last trimester of gestation and gastric intubation of 40mg Zn from soluble zinc methionine (ZnMet) to suckling pigs at birth and on day 7 and 14 (weaning) on small intestinal morphology, Zn status and bacterial translocation in early-weaned pigs. At weaning, pigs were challenged with an intramuscular injection of saline without or with 120microg/kg BW of lipopolysaccharide (LPS; from Escherichia coli O26:B6) and were euthanized 24h later prior to collection of intestinal lymph nodes and small intestinal sections. Zinc concentration in serum 7 days after birth and at weaning were higher in pigs from ZnAA-supplemented sows and those receiving gastric intubation with ZnMet (P=0.05 and P<0.0001, respectively). Post-weaning liver tissue concentrations for Zn (P<0.0001) and Fe (P=0.04) were higher and for Cu lower (P<0.0001) in pigs intubated with ZnMet. Pigs from ZnAA-supplemented compared with control-fed sows tended (P<0.1) to have increased villi height and villus:crypt ratio in the jejunum and higher (P=0.1) goblet cell counts in the ileum. Goblet cell counts of ZnMet-intubated (P=0.03) and LPS-challenged pigs (P=0.05) were also higher in the jejunum. Supplementation of ZnAA to gestating sows increased (P=0.04) E. coli colony forming unit counts in the small intestinal mesenteric lymph nodes of early-weaned pigs. In conclusion, dietary addition of ZnAA to gestating sows and gastric intubation of ZnMet improved Zn status of suckling pigs.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
LS7413113	Lipopolysaccharides from Escherichia coli O26:B6			Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: