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Suppressive Effect of E-64c on Ischemic Degradation of Cerebral Proteins Following Occlusion of the Middle Cerebral Artery in Rats

Suppressive Effect of E-64c on Ischemic Degradation of Cerebral Proteins Following Occlusion of the Middle Cerebral Artery in Rats

T Inuzuka, A Tamura, S Sato, T Kirino, I Toyoshima, T Miyatake

Brain Res. 1990 Aug 27;526(1):177-9.

PMID: 1706637

Abstract:

Microtubule-associated protein 2 (MAP2) levels in the left cerebral hemisphere decreased significantly 3 days after occlusion of the left middle cerebral artery in rats to 29 +/- 16.3% of control levels. Since MAP2 is one of the substrates of calpain, E-64c, a synthetic calpain inhibitor, was administered at a dose of 400 mg/kg twice a day for 3 days, with the first dose being given before the production of ischemia. This depletion was significantly inhibited in vivo by E-64c (P less than 0.05) to increase MAP2 levels to 55 +/- 25.7% of control levels. E-64c had no significant effect on the ischemia-induced depletion of myelin-associated glycoprotein. Sham-operated rats were used as controls. Our results suggest that calpain is partially involved in the degradation of MAP2, and that the use of calpain inhibitors can be a useful clinical approach to cerebral ischemia.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP76684894	E-64c		76684-89-4	Price

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