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Suppressive Efficacies of Antimicrobial Agents Against Human Peripheral-Blood Mononuclear Cells Stimulated With T Cell Mitogen and Bacterial Superantigen

Suppressive Efficacies of Antimicrobial Agents Against Human Peripheral-Blood Mononuclear Cells Stimulated With T Cell Mitogen and Bacterial Superantigen

Masaki Maeda, Hidetoshi Ishii, Sachiko Tanaka, Kenji Onda, Toshihiko Hirano

Arzneimittelforschung. 2010;60(12):760-8.

PMID: 21265468

Abstract:

The immunomodulatory efficacies of 12 antimicrobial agents clinically used were examined against T cell mitogen- or bacterial superantigen-induced proliferation of peripheral-blood mononuclear cells of healthy subjects. Minocycline (CAS 13614-98-7), rifampicin (CAS 13292-46-1), trimethoprim (CAS 738-70-5), and ribavirin (CAS 36791-04-5) significantly inhibited the proliferation of mitogen-stimulated mononuclear cells at 1-100 microg/ ml (p < 0.001), whereas ofloxacin (CAS 82419-36-1) enhanced the proliferation (p < 0.001). Ampicillin (CAS 69- 53-4), lincomycin (CAS 859-18-7), vancomycin (CAS 1404-93-9), sulfamethoxazole (CAS 723-46-6), fosfomycin (CAS 26016-99-9), colistin (CAS 1264-72-8), and polymyxin B (CAS 1405-20-5) showed no significant effect. Minocycline, rifampicin, trimethoprim, and ribavirin also inhibited the proliferation of superantigen-stimulated peripheral-blood mononuclear cells at 1-100 microg/ml (<0.001), whereas ofloxacin stimulated the proliferation (p < 0.001). Rifampicin and minocycline at 10-100 microg/ml significantly inhibited interleukin-2 production from mitogen- or superantigen-stimulated peripheral-blood mononuclear cells (p < 0.025). These results suggest that certain kinds of antimicrobial agents inhibited the proliferation of mitogen- and superantigen-stimulated human peripheral-blood mononuclear cells and suppressed interleukin-2 production from these cells. The ofloxacin effect is immunostimulative, while the drug did not influence the interleukin-2 production.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP13292461-A	Rifampicin - CAS 13292-46-1		13292-46-1	Price
AP13614987-B	Minocycline, Hydrochloride - CAS 13614-98-7		13614-98-7	Price

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