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Surface Electric Charge of the Active and Inactive Polymorphs of Chloramphenicol Palmitate

Surface Electric Charge of the Active and Inactive Polymorphs of Chloramphenicol Palmitate

R Kaliszan

J Pharm Sci. 1986 Feb;75(2):187-9.

PMID: 3958931

Abstract:

Higher zeta-potential values were found for the crystalline particles of polymorph A when compared with polymorph B of chloramphenicol palmitate when measured at identical conditions. In the case of the thermomicroscopically prepared crystal sample being a mixture of the polymorphs, the resulting zeta potential was higher than that measured for pure form B and lower than that found for form A. It has been assumed that the zeta potential reflects differences in the surface properties of the polymorphs. These differences are briefly discussed from the point of view of the adsorption of the charge-generating ions as well as of the marked differences in bioactivity reported for the polymorphs.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP530438-C	Chloramphenicol palmitate polymorph A		530-43-8	Price

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