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Surface Modification of PDMS Microchips With Poly(ethylene Glycol) Derivatives for μTAS Applications

Surface Modification of PDMS Microchips With Poly(ethylene Glycol) Derivatives for μTAS Applications

Richard Piffer Soares de Campos, Inez Valeria Pagotto Yoshida, José Alberto Fracassi da Silva

Electrophoresis. 2014 Aug;35(16):2346-52.

PMID: 24723304

Abstract:

In this work is presented a method for the modification of native PDMS surface in order to improve its applicability as a substrate for microfluidic devices, especially in the analysis of nonpolar analytes. Therefore, poly(ethylene glycol) divinyl ether modified PDMS substrate was obtained by surface modification of native PDMS. The modified substrate was characterized by attenuated total reflectance infrared spectroscopy, water contact angle measurements, and by evaluating the adsorption of rhodamine B and the magnitude of the EOF mobility. The reaction was confirmed by the spectroscopic evaluation. The formation of a well-spread water film over the surface immediately after the modification was an indicative of the modified surface hydrophilicity. This characteristic was maintained for approximately ten days, with a gradual return to a hydrophobic state. Fluorescence assays showed that the nonpolar adsorption property of PDMS was significantly decreased. The EOF mobility obtained was 3.6 × 10(-4) cm(2) V(-1) s(-1) , higher than the typical values found for native PDMS. Due to the better wettability promoted by the modification, the filling of the microchannels with aqueous solutions was facilitated and trapping of air bubbles was not observed.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP50856263	Poly(ethylene glycol) divinyl ether		50856-26-3	Price

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