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Surface Modification of Polyisobutylene via Grafting Amino Acid-Based Poly (acryloyl-6-aminocaproic Acid) as Multifunctional Material

Surface Modification of Polyisobutylene via Grafting Amino Acid-Based Poly (acryloyl-6-aminocaproic Acid) as Multifunctional Material

Yanqiu Du, Chunming Li, Jing Jin, Chao Li, Wei Jiang

Colloids Surf B Biointerfaces. 2018 Jan 1;161:73-82.

PMID: 29054046

Abstract:

Amino acid-based P(acryloyl-6-aminocaproic acid) (PAACA) brushes were fabricated on polyisobutylene (PIB) surface combined with plasma pre-treatment and UV-induced grafting polymerization to construct an antifouling and functional material. The hydrophilicity and hemocompatibility of PIB were largely improved by surface modification of AACA, which were confirmed by water contact angle and platelet adhesion, respectively. PAACA brushes were precisely located onto the surface of PIB to create a patterned PIB-g-PAACA structure, and then the carboxyl groups on PAACA was activated to immobilize functional protein-Concanavalin A (Con A). The obtained Con A-coupled microdomains could further capture erythrocytes. This method developed a platform on commercial PIB surface via amino acid-based polymer brushes which had a promising application in drug delivery and disease diagnosis.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP9003274	Polyisobutylene		9003-27-4	Price

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