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[Surveillance for Occult HBV Infection and HBsAg Variants in Blood Donors]

[Surveillance for Occult HBV Infection and HBsAg Variants in Blood Donors]

Chang-rong Chen, Quan Yuan, Sheng-xiang Ge, Shan-hai Ou, Hong-ying Ni, Yong-chang Zhang, Bin Pei, An Li, Qiang Yan, Yong-cai Lin, Qing-rui Chen, Ning-shao Xia, Jun Zhang

Bing Du Xue Bao. 2009 May;25(3):178-84.

PMID: 19634759

Abstract:

Occult hepatitis B virus (HBV) infection status of blood donors in a southern city in China was investigated by immunological assays and nucleic acid testing. Overall, 17 (0.19%, 95% CI: 0.11%-0.30%) of the 9023 HBsAg negative samples were found to be positive for the presence of HBV DNA. "A" epitope sequences were obtained from 14 among them. Mutation(s) in aa124-aa147 existed in 6 (42.9%, 6/14) samples and 4 (66.7%, 4/6)were G145R mutation. Ratio of genotype C in occult donors (10/17) was statistically higher than HBs-positive donors (0/15, P<0.01), which implied that HBV genotype C leaded to occult infection more easily.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP393121749	AA147		393121-74-9	Price

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