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Suzuki Coupling of Potassium Cyclopropyl- And Alkoxymethyltrifluoroborates With Benzyl Chlorides

Virginie Colombel, Frederik Rombouts, Daniel Oehlrich, Gary A Molander

J Org Chem. 2012 Mar 16;77(6):2966-70.

PMID: 22390789

Abstract:

Efficient Csp(3)-Csp(3) Suzuki couplings have been developed with both potassium cyclopropyl- and alkoxymethyltrifluoroborates. Moderate to good yields have been achieved in the cross-coupling of potassium cyclopropyltrifluoroborate with benzyl chlorides possessing electron-donating or electron-withdrawing substituents. Benzyl chloride was also successfully cross-coupled to potassium alkoxymethyltrifluoroborates derived from primary, secondary, and tertiary alcohols.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP1065010878 Potassium cyclopropyltrifluoroborate Potassium cyclopropyltrifluoroborate 1065010-87-8 Price
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