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Swainsonine-containing Plants and Their Relationship to Endophytic Fungi

Swainsonine-containing Plants and Their Relationship to Endophytic Fungi

Daniel Cook, Dale R Gardner, James A Pfister

J Agric Food Chem. 2014 Jul 30;62(30):7326-34.

PMID: 24758700

Abstract:

Swainsonine, an indolizidine alkaloid with significant physiological activity, is an α-mannosidase and mannosidase II inhibitor that alters glycoprotein processing and causes lysosomal storage disease. Swainsonine is present in a number of plant species worldwide and causes severe toxicosis in livestock grazing these plants. Consumption of these plants by grazing animals leads to a chronic wasting disease characterized by weight loss, depression, altered behavior, decreased libido, infertility, and death. This review focuses on the three plant families and the associated taxa that contain swainsonine; the fungi that produce swainsonine, specifically the fungal endophytes associated with swainsonine-containing taxa; studies investigating the plant, endophyte, and swainsonine relationship; the influence of environmental factors on swainsonine concentrations in planta; and areas of future research.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP72741878	Swainsonine		72741-87-8	Price

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