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Swertisin, a C-glucosylflavone, Ameliorates Scopolamine-Induced Memory Impairment in Mice With Its Adenosine A1 Receptor Antagonistic Property

Swertisin, a C-glucosylflavone, Ameliorates Scopolamine-Induced Memory Impairment in Mice With Its Adenosine A1 Receptor Antagonistic Property

Hyung Eun Lee, Se Jin Jeon, Byeol Ryu, Se Jin Park, Sang Yoon Ko, Younghwan Lee, Eunji Kim, Sunhee Lee, Haneul Kim, Dae Sik Jang, Jong Hoon Ryu

Behav Brain Res. 2016 Jun 1;306:137-45.

PMID: 26996316

Abstract:

Swertisin, a C-glucosylflavone isolated from Swertia japonica, has been known to have anti-inflammatory or antidiabetic activities. Until yet, however, its cognitive function is not investigated. In the present study, we endeavored to elucidate the effects of swertisin on cholinergic blockade-induced memory impairment. Swertisin (5 or 10mg/kg, p.o.) significantly ameliorated scopolamine-induced cognitive impairment in the several behavioral tasks. Also, single administration of swertisin (10mg/kg, p.o.) in normal naïve mice enhanced the latency time in the passive avoidance task. In addition, the ameliorating effect of swertisin on scopolamine-induced memory impairment was significantly antagonized by a sub-effective dose of N6-cyclopentyladenosine (CPA, 0.1mg/kg, i.p). The adenosine A1 receptor antagonistic property of swertisin was confirmed by receptor binding assay. Furthermore, the administration of swertisin significantly increased the phosphorylation levels of hippocampal or cortical protein kinase A (PKA, 5 or 10mg/kg) and CREB (10mg/kg), and co-administration of CPA (0.1mg/kg, i.p) blocked the increased phosphorylated levels of PKA and CREB in the both cortex and hippocampus. Taken together, these results indicate that the memory-ameliorating effects of swertisin may be, in part, mediated through the adenosinergic neurotransmitter system, and that swertisin may be useful for the treatment of cognitive dysfunction observed in several diseases such as Alzheimer's disease.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP6991102	Swertisin		6991-10-2	Price

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