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Swinholide J, a Potent Cytotoxin From the Marine Sponge Theonella Swinhoei

Swinholide J, a Potent Cytotoxin From the Marine Sponge Theonella Swinhoei

Simona De Marino, Carmen Festa, Maria Valeria D'Auria, Thierry Cresteil, Cecile Debitus, Angela Zampella

Mar Drugs. 2011;9(6):1133-41.

PMID: 21747751

Abstract:

In our ongoing search for new pharmacologically active leads from Solomon organisms, we have examined the sponge Theonella swinhoei. Herein we report the isolation and structure elucidation of swinholide A (1) and one new macrolide, swinholide J (2). Swinholide J is an unprecedented asymmetric 44-membered dilactone with an epoxide functionality in half of the molecule. The structural determination was based on extensive interpretation of high-field NMR spectra and HRESIMS data. Swinholide J displayed potent in vitro cytotoxicity against KB cells (human nasopharynx cancer) with an IC(50) value of 6 nM.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42413786	Swinholide A from Theonella swinhoei			Price

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