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Symmetric Molecules With 1,4-triazole Moieties as Potent Inhibitors of Tumour-Associated Lactate dehydrogenase-A

Symmetric Molecules With 1,4-triazole Moieties as Potent Inhibitors of Tumour-Associated Lactate dehydrogenase-A

Abdul-Malek S Altamimi, Ahmed M Alafeefy, Agnese Balode, Igor Vozny, Aleksandrs Pustenko, Mohey Eldin El Shikh, Fatmah A S Alasmary, Sherif A Abdel-Gawad, Raivis Žalubovskis

J Enzyme Inhib Med Chem. 2018 Dec;33(1):147-150.

PMID: 29199484

Abstract:

A series of symmetric molecules incorporating aryl or pyridyl moieties as central core and 1,4-substituted triazoles as a side bridge was synthesised. The new compounds were investigated as lactate dehydro-genase (LDH, EC 1.1.1.27) inhibitors. The cancer associated LDHA isoform was inhibited with IC50 = 117-174 µM. Seven compounds exhibited better LDHA inhibition (IC50 117-136 µM) compared to known LDH inhibitor - galloflavin (IC50 157 µM).

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP568809	Galloflavin		568-80-9	Price

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