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Synergistic Activity of Ceftazidime-Avibactam and Aztreonam Against Serine and metallo-β-lactamase-producing Gram-Negative Pathogens

Eric Wenzler, Matthew F Deraedt, Amanda T Harrington, Larry H Danizger

Diagn Microbiol Infect Dis. 2017 Aug;88(4):352-354.

PMID: 28602518

Abstract:

This study assessed the in vitro synergy between ceftazidime, aztreonam, and ceftazidime-avibactam against serine and metallo-β-lactamase (MBL)-producing pathogens via the Etest MIC:MIC ratio and Agar-Etest synergy methods. The combination of aztreonam and ceftazidime-avibactam was synergistic against all Enterobacteriaceae. None of the tested combinations were consistently synergistic against IMP-producing P. aeruginosa.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP78110380-A Aztreonam Aztreonam 78110-38-0 Price
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