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Synergistic Effect of Carbon Nanotubes and Graphene for High Performance Cellulose Acetate Membranes in Biomedical Applications

Synergistic Effect of Carbon Nanotubes and Graphene for High Performance Cellulose Acetate Membranes in Biomedical Applications

Mariana Ioniță, Livia Elena Crică, Stefan Ioan Voicu, Sorina Dinescu, Florin Miculescu, Marieta Costache, Horia Iovu

Carbohydr Polym. 2018 Mar 1;183:50-61.

PMID: 29352892

Abstract:

Comparative evaluation of innovative combinations of three types of carbon nanomaterial (CNM) highlighted membranes with important potential for biomedical applications. Non-solvent induced phase separation coupled with ultrasound technique was used to generate membranes comprised of (i) cellulose acetate/ammonia functionalized carbon nanotubes (CA/CNT), (ii) cellulose acetate/ammonia functionalized graphene oxide (CA/GO), and (iii) cellulose acetate/CNT-GO. Structural, topographical and thermal features as well as water and ethanol permeation, bovine serum albumin (BSA) and haemoglobin (Hb) rejection were evaluated. Biocompatibility in terms of cytotoxicity, cell proliferation and adhesion were explored using a 3T3E1 cell line. The formation of amorphous structures, within which the CNMs were well dispersed, facilitated the development of smoother topographies. Addition of CNMs generated morphological changes influencing a decrease in water and ethanol fluxes. Furthermore, CNMs concentrated within the membrane skin layer exhibited repellent effects against BSA and Hb molecules and excellent cytocompatibility.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
LS71738	Graphene oxide, ammonia functionalized			Price

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