Home
Resources
Publications
Synergy Between Polymer Crystallinity and Nanoparticles Size for Payloads Release

Synergy Between Polymer Crystallinity and Nanoparticles Size for Payloads Release

Yupaporn Niyom, Treethip Phakkeeree, Adrian Flood, Daniel Crespy

J Colloid Interface Sci. 2019 Aug 15;550:139-146.

PMID: 31063872

Abstract:

Drug delivery from polymer nanocarriers is usually achieved by designing polymers so that they release drugs by cleavage of labile bonds, or by preparing nanoparticles that swell or collapse in response to external stimuli. Herein, we unravel the importance of polymer crystallinity in release profiles of drugs encapsulated in polymer nanoparticles. Polycaprolactone, as a model biocompatible and biodegradable semi-crystalline polymer, was processed into nanoparticles by the miniemulsion-solvent evaporation technique. The crystallinity of the nanoparticles was controlled by the polymer concentration, size of nanoparticles, and the composition of mixtures with amorphous polymers such as poly(vinyl formal) and polystyrene. Crystallinity decreased significantly with decreasing nanoparticle diameter. Release profiles of drugs were found to be dependent on an interplay of nanoparticle size and crystallinity. Therefore, crystallinity can be used for tuning the release profiles of nanoparticles.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP9003332	Poly(vinyl formal)		9003-33-2	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: