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Syntheses of (2')3'-15N-amino-(2')3'-deoxyguanosine and Determination of Their pKa Values by 15N NMR Spectroscopy

Syntheses of (2')3'-15N-amino-(2')3'-deoxyguanosine and Determination of Their pKa Values by 15N NMR Spectroscopy

Qing Dai, Charles R Lea, Jun Lu, Joseph A Piccirilli

Org Lett. 2007 Aug 2;9(16):3057-60.

PMID: 17629287

Abstract:

2'-Amino-2'-deoxyguanosine and 3'-amino-3'-deoxyguanosine are valuable probes for investigating the metal ion interactions at the active site of the group I ribozyme. However, these experiments require a thorough understanding of the protonation state of the amino group at a specific pH. Here, we describe the first syntheses of 2'-15N-amino-2'-deoxyadenosine, 2'-15N-amino-2'-deoxyguanosine, and 3'-15N-amino-3'-deoxyguanosine. The 15N-enriched nucleus allows convenient and accurate determination of the amine pKa by 15N NMR.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP285978247	Glyphosate-2-13C,15N		285978-24-7	Price

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