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Syntheses of Deuterium Labeled Prenyldiphosphate and Prenylcysteine Analogues for in Vivo Mass Spectrometric Quantification

Thangaiah Subramanian, Karunai Leela Subramanian, Manjula Sunkara, Fredrick O Onono, Andrew J Morris, H Peter Spielmann

J Labelled Comp Radiopharm. 2013 Jun 30;56(8):370-5.

PMID: 24285475

Abstract:

A Wittig reaction employing Li(CD3)2CP(C6H5)3 was used to prepare d6-farnesol and d6-geranylgeraniol. Reductive amination of aniline-2,3,4,5,6-d5 was used to prepare the unnatural isoprenoid analogues d5-anilinogeraniol and d5-anilinofarnesol. All of these deuterated isoprenols were elaborated into their diphosphate and cysteine thioether derivatives suitable for use as stable-isotope labeled standards for quantitative mass spectrometric analysis.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP1258063567-A 11-Deoxycortisol-D5 (2,2,4,6,6-D5) 11-Deoxycortisol-D5 (2,2,4,6,6-D5) 1258063-56-7 Price
AP1262769878 Isophorone-2,4,4,6,6-d5 Isophorone-2,4,4,6,6-d5 1262769-87-8 Price
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