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Synthesis, Analytical Characterization and Initial Capillary Electrophoretic Use in Acidic Background Electrolytes of a New, Single-Isomer Chiral Resolving Agent: hexakis(2,3-di-O-acetyl-6-O-sulfo)-alpha-cyclodextrin

Synthesis, Analytical Characterization and Initial Capillary Electrophoretic Use in Acidic Background Electrolytes of a New, Single-Isomer Chiral Resolving Agent: hexakis(2,3-di-O-acetyl-6-O-sulfo)-alpha-cyclodextrin

Shulan Li, Gyula Vigh

Electrophoresis. 2003 Aug;24(15):2487-98.

PMID: 12900860

Abstract:

The sodium salt of hexakis(2,3-di-O-acetyl-6-O-sulfo)-alpha-CD (HxDAS), the first member of the family of single-isomer, fully sulfated alpha-CDs, has been synthesized and used for the initial capillary electrophoretic separation of the enantiomers of nonionic, weak acid, weak base, and ampholytic analytes. HxDAS complexes less strongly with many of the analytes tested than the analogous beta- and gamma-cyclodextrin derivatives, namely, heptakis(2,3-di-O-acetyl-6-O-sulfo)-beta-cyclodextrin (HDAS) and octakis(2,3-di-O-acetyl-6-O-sulfo)-gamma-cyclodextrin (ODAS). Nevertheless, it facilitated the separation of the enantiomers of a large number of weak electrolyte and nonelectrolyte analytes in acidic aqueous background electrolytes. For all analytes, the effective mobilities and separation selectivities as a function of the background electrolyte concentration of HxDAS followed the trends that were found for HDAS and ODAS.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
LS741344	Hexakis (6-O-tertbutyl-dimethylsilyl)-α-cyclodextrin			Price

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