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Synthesis and Anticancer Activity of Novel Ureas and Sulfamides Incorporating 1-Aminotetralins

Synthesis and Anticancer Activity of Novel Ureas and Sulfamides Incorporating 1-Aminotetralins

Bünyamin Özgeriş, Yusuf Akbaba, Özlem Özdemir, Hasan Türkez, Süleyman Göksu

Arch Med Res. 2017 Aug;48(6):513-519.

PMID: 29248174

Abstract:

Background and aims:
In the present study, a series of ureas and sulfamides derived from 1-aminotetralins were synthesized. For this purpose, urea and sulfamide analogues were synthesized from the reactions of substituted 1-aminotetralins with N,N-dimethylcarbamoyl chloride and N,N-dimethylsulfamoyl chloride. The anticancer activity of newly synthesized compounds was tested against human U-87MG glioblastoma and PC-3 prostate cancer cell lines. Cytotoxicity was examined using MTT and LDH release assays.
Results:
The obtained data revealed that tested compounds showed a variable degree of cytotoxic activity against the tested cell lines. 3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)-1,1-dimethylurea (9) and 3-(6-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)-1,1-dimethylurea (10) proved to be the most active cytotoxic members in this study.
Conclusions:
These two compounds could be considered as possible anticancer agents.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP139332642	4-(N,N-Dimethylsulfamoyl)-7-piperazino-benzofurazan		139332-64-2	Price

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