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Synthesis and Antidiabetic Activity of Some New chromonyl-2,4-thiazolidinediones

Synthesis and Antidiabetic Activity of Some New chromonyl-2,4-thiazolidinediones

Oya Bozdağ-Dündar, Meltem Ceylan-Unlüsoy, Eugen J Verspohl, Rahmiye Ertan

Arzneimittelforschung. 2007;57(8):532-6.

PMID: 17915640

Abstract:

A series of chromonyl-2,4-thiazolidinediones (VIa-f) and chromonyl-2,4-imidazolidinediones (VIIa-f) was prepared by Knoevenagel reaction of substituted benzyl-2,4-thiazolidinediones (IVa-f) and substituted benzyl-2,4-imidazolidinediones (Va-f) with chromone-3-carboxaldehyde (I). The prepared compounds were tested for their insulinotropic activities in INS-1 cells. Compounds VIa, VIb, VId and VIIe (at lower concentration; 1 microg/ml) were able to increase insulin release in the presence of 5.6 mmol/l glucose; their effects were lower than that of glibenclamide (CAS 10238-21-8). The activity of the most potent compound (VId) was still 9% less than that of glibenclamide.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP10238218-D	Glyburide - CAS 10238-21-8		10238-21-8	Price

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