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Synthesis and Antimicrobial Activity of Some New Hydrazones of 4-fluorobenzoic Acid Hydrazide and 3-acetyl-2,5-disubstituted-1,3,4-oxadiazolines

Sevim Rollas, Nehir Gulerman, Habibe Erdeniz

Farmaco. 2002 Feb;57(2):171-4.

PMID: 11902660

Abstract:

A series of hydrazide hydrazones and 1,3,4-oxadiazolines of 4-fluorobenzoic acid hydrazide were prepared and evaluated as potential antimicrobial agents and were tested for their antibacterial and antifungal activities against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Candida albicans. From these compounds, 4-fluorobenzoic acid[(5-nitro-2-furanyl)methylene]hydrazide (1a) showed equal activity with ceftriaxone against S. aureus. In addition, the MIC values of compounds 1c, 1d and 2a for the same strain were in the range of those reported for ceftriaxone according to NCCLS 1997.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP285977824 4-Fluorobenzoic acid-α-13C-2,3,5,6-d4 4-Fluorobenzoic acid-α-13C-2,3,5,6-d4 285977-82-4 Price
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