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Synthesis and Antimicrobial Evaluation of Thieno[2,3-d]-pyrimidine, Thieno[2',3':4,5]pyrimido[1,2-a][1,3,5]triazine, Thieno[2,3-d]-1,3-thiazine and 1,2,4-Triazole Systems

Synthesis and Antimicrobial Evaluation of Thieno[2,3-d]-pyrimidine, Thieno[2',3':4,5]pyrimido[1,2-a][1,3,5]triazine, Thieno[2,3-d]-1,3-thiazine and 1,2,4-Triazole Systems

Magdy Mohamed Hemdan, Heba Kamal Abd El-Mawgoude

Chem Pharm Bull (Tokyo). 2015;63(10):812-8.

PMID: 26423038

Abstract:

The reaction of lauroyl isothiocyanate with ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate gave ethyl 2-(3-dodecanoylthioureido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate 3. Compound 3 could serve as a main building block in synthesis of the target heterocyclic systems like thieno[2,3-d]-pyrimidine, thieno[2',3':4,5]pyrimido[1,2-a][1,3,5]triazine, thieno[2,3-d]-1,3-thiazine and 1,2,4-triazole systems attached to the lauryl group. The structures of the synthesized target heterocyclic compounds were confirmed by microanalytical and spectral data. The antimicrobial activity of some of the synthesized compounds was tested.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP958300066	2,3,4,6-Tetra-O-pivaloyl-β-D-glucopyranosyl isothiocyanate		958300-06-6	Price

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