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Synthesis and Antimicrobial Studies of 4-[3-(3-Fluorophenyl)-4-formyl-1

Jedidiah Whitt, Cameron Duke, Mohamad Akbar Ali, Steven A Chambers, Md Mahbub Kabir Khan, David Gilmore, Mohammad A Alam

ACS Omega. 2019 Aug 21;4(10):14284-14293.

PMID: 31508552

Abstract:

Microbial resistance to antibiotics is an urgent and worldwide concern. Several pyrazole-derived hydrazones were synthesized by using benign reaction conditions. Several of these molecules are potent growth inhibitors of drug-resistant strains of Staphylococcus aureus and Acinetobacter baumannii with minimum inhibitory concentration values as low as 0.39 μg/mL. Furthermore, these molecules are nontoxic to human cells at high concentrations. Some of these molecules were tested for their ability to disrupt the bacterial membrane by using the SYTO-9/propidium iodide (BacLight) assay.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
LS793939 3-(4-fluorophenyl)aminocarbonylphenylboronic acid 3-(4-fluorophenyl)aminocarbonylphenylboronic acid Price
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