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Synthesis and Antimycotic Activity of Some Benzyloxyimino Compounds

L Garuti, G Giovanninetti, A Ferranti, A Chiarini, G Bertocchi, P Sabatino, P Brigidi

Pharmazie. 1987 Jun;42(6):378-81.

PMID: 3671457

Abstract:

Some benzyloxyimio compounds, related to oxiconazole and having a 1H-indole or 1H-benzimidazole moiety, have been synthesized and tested in vitro for their antimycotic activity against Candida tropicalis and C. albicans. The most active was showed to be 0-(2,4-dichlorobenzyl)-1-benzyl-5-nitro-1H-benzimidazole-2-carboxaldehyd e oxime (MIC: 25 micrograms/ml against both microorganisms). A structural feature important for the biological activity of the series appears to be presence of a benzimidazole nucleus substituted by an electron withdrawing group.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
CS31042612 Oxiconazole Related Compound C Oxiconazole Related Compound C Price
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