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Synthesis and Antiviral Activity of a Series of 1'-substituted 4-aza-7,9-dideazaadenosine C-nucleosides

Aesop Cho, Oliver L Saunders, Thomas Butler, Lijun Zhang, Jie Xu, Jennifer E Vela, Joy Y Feng, Adrian S Ray, Choung U Kim

Bioorg Med Chem Lett. 2012 Apr 15;22(8):2705-7.

PMID: 22446091

Abstract:

A series of 1'-substituted analogs of 4-aza-7,9-dideazaadenosine C-nucleoside were prepared and evaluated for the potential as antiviral agents. These compounds showed a broad range of inhibitory activity against various RNA viruses. In particular, the whole cell potency against HCV when R=CN was attributed to inhibition of HCV NS5B polymerase and intracellular concentration of the corresponding nucleoside triphosphate.

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AP444315188 PSS-Vinyl-Heptaisobutyl substituted PSS-Vinyl-Heptaisobutyl substituted 444315-18-8 Price
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