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Synthesis and Biodistribution of 34mCl-labeled 2-chloro-2-deoxy-d-glucose: A Major Impurity in [18F]FDG Injection

Synthesis and Biodistribution of 34mCl-labeled 2-chloro-2-deoxy-d-glucose: A Major Impurity in [18F]FDG Injection

Toshimitsu Fukumura, Makoto Takei, Kazutoshi Suzuki

Appl Radiat Isot. 2008 Dec;66(12):1905-9.

PMID: 18706823

Abstract:

No-carrier-added 2-[(34m)Cl]chloro-2-deoxy-d-glucose ([(34m)Cl]ClDG) was prepared via nucleophilic displacement reaction of 1, 3, 4, 6-tetra-O-acetyl-2-trifluoromethansulfonyl mannose with K[(34m)Cl]Cl/kryptofix 222 complex using (34m)Cl(-) produced via the (nat)S(alpha, 2n) nuclear reactions. The synthesis time from enrichment of [(34m)Cl]Cl(-) was approximately 45min and the radiochemical yield was 79.6+/-6.7% (n=3) with decay correction. Animal PET studies showed that the behavior of [(34m)Cl]ClDG was quite different from that of [(18)F]FDG. [(34m)Cl]ClDG did not accumulate in any organ and was excreted as [(34m)Cl]ClDG.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP14685791-A	2-Chloro-2-deoxy-D-glucose		14685-79-1	Price

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