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Synthesis and Biological Activities of Novel furo[2,3,4-jk][2]benzazepin-4(3H)-one Derivatives

Synthesis and Biological Activities of Novel furo[2,3,4-jk][2]benzazepin-4(3H)-one Derivatives

Kumiko Ando, Yukiko Akai, Jun-Ichi Kunitomo, Takehiko Yokomizo, Hidemitsu Nakajima, Tadayoshi Takeuchi, Masayuki Yamashita, Shunsaku Ohta, Takahiro Ohishi, Yoshitaka Ohishi

Org Biomol Chem. 2007 Feb 21;5(4):655-63.

PMID: 17285174

Abstract:

A novel seven-membered lactam formation method has been established by intramolecular ring closure reaction of 4-bromo-(E)-3-[(2-alkylvinyl)carbonylamino]benzo[b]furans under Heck coupling conditions. A number of furo[2,3,4-jk][2]benzazepin-4(3H)-ones, tricyclicbenzo[b]furans, have been prepared by this method and evaluated for their leukotriene B(4) (LTB(4)) receptor and poly(ADP-ribose)polymerase-1 (PARP-1) inhibitory activities.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR4243736	JK-2			Price

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