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Synthesis and Biological Activities of Reveromycin A and Spirofungin A Derivatives

Takeshi Shimizu, Takeo Usui, Makoto Fujikura, Makoto Kawatani, Tomoharu Satoh, Kiyotaka Machida, Naoki Kanoh, Je-Tae Woo, Hiroyuki Osada, Mikiko Sodeoka

Bioorg Med Chem Lett. 2008 Jul 1;18(13):3756-60.

PMID: 18519164

Abstract:

Various derivatives of reveromycin A, an inhibitor of eukaryotic cell growth, and spirofungin A, focusing on the 5S hydroxyl group and C18 hemisuccinyl group, were synthesized and their inhibitory effects on both the isoleucyl-tRNA synthetase activity and the survival of osteoclasts, and activities on the morphological reversion of src(ts)-NRK cells were examined. It was found that 2,3-dihydroreveromycin A is the promising derivative of reveromycin A based on the activity and stability.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP134615375 Reveromycin A Reveromycin A 134615-37-5 Price
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