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Synthesis and Biological Activity of 23-hydroxybetulinic Acid C-28 Ester Derivatives as Antitumor Agent Candidates

Yi Bi, Jinyi Xu, Fei Sun, Xiaoming Wu, Wencai Ye, Yijun Sun, Wenwen Huang

Molecules. 2012 Jul 25;17(8):8832-41.

PMID: 22832884

Abstract:

23-Hydroxybetulinic acid (1) served as the precursor for the synthesis of C-28 ester derivatives. The target compounds were evaluated in vitro for their antitumor activities against five cell lines (A549, BEL-7402, SF-763, B16 and HL-60). Among the obtained compounds, 6i had the most potent antitumor activity, with the IC(50 values of 8.35 µM in HL-60 cells and showed similar antitumor activity as cyclophosphamide in H22 liver tumor and as 5-fluorouracil in B16 melanoma in vivo.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP85999402-B 23-Hydroxybetulinic acid 23-Hydroxybetulinic acid 85999-40-2 Price
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